Ecological Models for Gene Therapy. I. Models for Intraorganismal Ecology

TitleEcological Models for Gene Therapy. I. Models for Intraorganismal Ecology
Publication TypeJournal Article
Year of Publication2014
AuthorsPocheville A, Montévil M
JournalBiol Theory
Volume9
Pagination401–413
ISSN1555-5542, 1555-5550
KeywordsCognitive Psychology, Ecosystem engineering, evolutionary biology, Inertial dynamics, Intraorganismal ecology, niche construction, nongenetic inheritance, Philosophy of Biology
Abstract

In this article, we discuss the perspective of intraorganismal ecology by investigating a family of ecological models. We consider two types of models. First-order models describe the population dynamics as being directly affected by ecological factors (here understood as nutrients, space, etc). They might be thought of as analogous to Aristotelian physics. Second-order models describe the population dynamics as being indirectly affected, the ecological factors now affecting the derivative of the growth rate (that is, the population acceleration), possibly through an impact on nongenetically inherited factors. Second-order models might be thought of as analogous to Galilean physics. In a companion article, we apply these ideas to a situation of gene therapy.

URLhttp://link.springer.com/article/10.1007/s13752-014-0190-y
DOI10.1007/s13752-014-0191-x